Lewis C. Cantley

Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley

Lewis C. Cantley, Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, is a world leader in cancer and metabolic disease research. His seminal discoveries have shed light on the regulation of ion pumps and other transport proteins, insulin-mediated regulation of glucose metabolism and the role of signal transduction networks in cell transformation. At Tufts Universit...

Cellular Control Mechanisms that Regulate Pyruvate Kinase M2 Activity and Promote Cancer Growth

Costas A. Lyssiotis, Dimitrios Anastasiou, Jason W. Locasale, Matthew G. Vander Heiden, Heather R. Christofk, Lewis C. Cantley* Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Koch Institute for Integrative Cancer Research, Department of Biology, Ma...

-Dependent Activation of the mTORC2 Kinase Complex

The era of cancer discovery.

Targeting PI3K/mTOR Signaling in Cancer

The American Association for Cancer Research (AACR) Special Conference on Targeting PI3K/mTOR Signaling in Cancer was held in San Francisco, California from February 24 to 27, 2011. The meeting was cochaired by Drs. Lewis C. Cantley, David M. Sabatini, and Funda Meric-Bernstam. The main focus of this event was the therapeutic potential of drugs targeting the PI3K/mTOR signaling pathway for the ...